Men with COPD may benefit from extra testosterone

Men with chronic obstructive pulmonary disease (COPD) -- which includes a number of lung problems such as emphysema that
make breathing difficult -- may benefit from an extra dose of testosterone, a new study indicates.


People with COPD are often easily fatigued and can't tolerate much physical exertion, probably because of loss of muscle
strength. Testosterone supplementation appears to increase lean muscle mass and strength in men with moderate to severe COPD
and low testosterone levels, LA BioMed researchers report in the American Journal of Respiratory and Critical Care Medicine.



"Patients with chronic lung disease have been found to benefit from rehabilitative therapies aimed at improving the function
of their muscles. This research suggests the anabolic drug testosterone improves muscle strength," says Dr. Richard Casaburi.
Casaburi and colleagues investigated the effects of testosterone supplementation in a study of 47 men with COPD and low
normal testosterone levels.


The participants were randomly assigned to one of four treatment groups: testosterone supplementation and strength training;
placebo and strength training; testosterone and no strength training; or placebo and no strength training. After 10 weeks,
both testosterone groups showed a significant increase in lean body mass. This amounted to an average increase of 2.3
kilograms (about 5 pounds) in those given testosterone alone and 3.3 kg (a little more than 7 pounds) in those who received
training and testosterone.


Moreover, the team found that maximum leg press strength increased 17 percent with either testosterone alone or training
alone, but by 27 percent with both. No adverse effects were seen. Despite these encouraging results, "further research in a
larger number of patients is needed before we can routinely recommend testosterone supplementation for men with COPD,"
Casaburi cautioned.


To contact Dr. Casaburi, please call David Feuerherd at 310-215-0234 / 310-222-2820 or e-mail him at dfissusmanagement.



The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) is one of the largest independent,
not-for-profit biomedical research institutes in Los Angeles County. Affiliated with both the David Geffen School of Medicine
at UCLA and the Harbor-UCLA Medical Center, the Institute has an annual budget of over $67 million and currently supports
more than 1,000 research studies in areas such as cardiology, emerging infections, cancer, women's health, reproductive
health, vaccine research, respiratory physiology, neonatology, molecular biology, and genetics. LA BioMed also plays a
pivotal role in the training of young physician - scientists and scientists-to-be and is active in promoting the health and
well being of nearby communities through community service programs that meet a variety of social and medical needs.


SOURCE: American Journal of Respiratory and Critical Care Medicine, October 15, 2004.


Contact: David Feuerherd

dfissuesmanagement

310-215-0234

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA
BioMed)